I will expand more on this in a later blog,.........Read this article from CNN.,.........................
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By Caleb Hellerman
CNN Senior Medical Producer
CENTRAL
FALLS, Rhode Island (CNN) -- A no-frills bar called Goober's, just
north of Providence, Rhode Island, is probably the last place you'd
expect to find a debate over cutting-edge addiction therapy. But this
is where Walter Kent, a retired mechanic, spends his Fridays. He helps
in the kitchen and hangs out in the bar, catching up with old friends.
Walter Kent talks to Dr. Sanjay Gupta about how the drug naltrexone has helped keep him sober.
Most
addiction specialists would call this playing with fire, or worse.
That's because for more than 30 years, Kent was a hard-core alcoholic.
His drinks of choice were Heineken beer and Jacob Ginger brandy, but
anything with alcohol would do.
"It's like a little kid wanting
a piece of candy. You see it, you want the taste of it." He closes his
eyes and sniffs the air, remembering the feeling. "You can be by
yourself, and all of a sudden get even a hint of alcohol, just the
smell of it, and say, 'Oh, I need a drink.' That sensation is not
something you can get rid of."
But today, Kent isn't tempted in
the least. He says the credit goes to a prescription medication -- a
pill called naltrexone. It's part of a new generation of anti-addiction
drugs that may turn the world of rehab on its head.
Dr. Mark
Willenbring, who oversees scientific research at the National Institute
on Alcoholism and Alcohol Abuse, says alcoholism has reached a point
similar to one depression reached 30 years ago -- when the development
of Prozac and other antidepressants took mental health care out of the
asylum and put it in homes and doctors' offices.
"There will be
a 'Prozac moment,' " Willenbring says, "when primary care doctors start
handling functional alcoholics." Video Watch Dr. Gupta: Are you an
alcoholic quiz »
Among the findings that are causing excitement:
'Addiction: Life on the Edge'
Dr.
Sanjay Gupta follows a mother, a writer, a student and a husband. Each
is an addict on a journey through recovery and relapse.
Sat & Sun, 8 p.m. ET on CNN
see full schedule »
•
A study led by Dr. Bankole Johnson of the University of Virginia found
that topiramate (Topamax) -- already used to treat epilepsy and
migraines -- reduced the number of days on which alcoholics drank
heavily, by 25 percent more than among alcoholics who got just therapy.
•
A federally funded study known as COMBINE compared cognitive-behavioral
therapy alone with therapy along with naltrexone. Patients receiving
both were more likely to stay abstinent and drank less if they did
relapse.
These findings highlight what's become increasingly
clear: Addiction is a brain disease, not just a failure of willpower.
Naltrexone and topiramate have slightly different mechanisms, but both
seem to block the release of brain chemicals that are linked to
pleasure and excitement. Unlike earlier drugs used to treat alcoholics,
neither is addictive or carries significant side effects. It does
appear that each might work better in certain subgroups -- topiramate
for repeat relapsers, and naltrexone in people with a strong family
history of alcoholism. Interactive: Addiction's lure to the brain »
Johnson
is a paid consultant to the company that makes Topamax, but his study
appeared in the Journal of the American Medical Association and he says
other medications can also work well. "I think everybody who's an
alcoholic should be given medication if they're willing to take it," he
says. "It's been shown over and over with research studies that effects
of medicine are over and above that of therapy. And if you're not
getting the medicine, it's a bit like having one hand tied behind your
back."
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Before
he found naltrexone, Kent had tried to quit drinking more times than he
can remember. "I was the kind of person who only drank if he was alone
or with somebody. Other than that, it was never a problem," he jokes
now. He did two stints in residential rehab programs and went to
countless AA meetings, but nothing worked. Kent is a giant of a man --
he stands a broad-shouldered 6 feet 5 inches tall, and has two sons who
played professional basketball in Israel -- but for most of his life,
he couldn't find the strength to put down the bottle. Video Watch Dr.
Gupta: Can a pill help you go cold turkey? »
It got worse in
2000, after an injury from falling off a ladder forced him to stop
working. Depressed and in pain, with time on his hands, Kent began
boozing from 8 o'clock in the morning, every morning. It went on a few
months until his wife, a woman he'd known since grammar school, handed
him an ad from a newspaper and an ultimatum: "She said, 'You're killing
the marriage, and you're killing yourself,' " Kent said. " ' Get help
or I'm gone.' "
The ad was recruiting alcoholics for research at
Roger Williams Hospital, part of Brown University. Kent signed up. It
was part of the COMBINE study. Kent got 16 weekly visits and also
something most addicts never hear about: medication. This time, he
stayed sober, even after his doctor took him off naltrexone. That was
more than eight years ago. Video Watch Walter Kent talk about his
struggle with alcohol »
Despite studies showing effectiveness,
established rehab programs have been slow to adopt the use of
medication. At Hazelden in Minneapolis, Minnesota, a small proportion
of patients receive anti-addiction drugs, but medical director Dr.
Kevin Clark says the traditional model -- based on intensive therapy
and the 12 steps popularized by Alcoholics Anonymous -- is still best.
"It is a disease of the brain, but it's a multifaceted disease. It has
a spiritual component, a behavioral component to it," says Clark. "Our
experience tells us that having the network of support and recovery is
what really makes the difference."
John Schwarzlose, executive
director of the Betty Ford Center, echoes that but takes a more
stringent approach. No patients at Betty Ford receive anti-addiction
drugs as part of treatment, although a handful of long-time addicts may
be referred to a prescribing physician once their stay is over. "Where
we battle with [the National Institute on Alcoholism and Alcohol Abuse]
is when they say we have trials of a new drug, and then proclaim this
is a treatment for alcoholism," says Schwarzlose. "They're smart
people, but they're missing how complex this disease is."
Health Library
* MayoClinic.com: Addiction
Schwarzlose
argues that Willenbring and Johnson are using the wrong measure of
success. He says abstinence is the only true measuring stick -- that an
alcoholic who is drinking less is just at a way station on the road to
relapse. "Naltrexone has reduced drinking, but once you're addicted,
there is no such thing as 'OK' drinking. This is one of those cases
where there's a real schism between the research and actual practice."
This
attitude frustrates Willenbring, who estimates that in the United
States only one addict in 10 has even heard about medication options.
"In most cases, the treatment is entirely nonmedical. Most people are
not even told about the medications that are available for treating
alcohol dependence, and I think that's a crime."
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Still,
medication is slowly creeping into mainstream addiction therapy. One
big advocate is Percy Menzies, a pharmacist and former sales
representative for DuPont, which developed naltrexone. His St. Louis,
Missouri-based Recovery Centers for America treats patients in an
on-site hospital, then refers them to outside physicians for follow-up
treatment. Along with therapy, virtually every patient is given
Vivitrol, a long-lasting form of naltrexone that's given monthly by
injection.
Kent says naltrexone saved his life. When the COMBINE
program was over, Kent's doctor told him to call if he felt the old
need for a drink coming back. But it never came. "I have yet to go back
and say, 'I have an urge for a drink,' " says Kent, lounging in
Goober's. "[My friends] will offer, 'You want a drink?' And I say, 'No,
I'm fine. I'll have a soda.' I'm fine with that. Because when there's
no urge, no craving, it doesn't bother me. I'm living proof this can
happen."